AI/ML startups in San Francisco

Proximal

San Francisco

Proximal builds realistic training environments that mirror software engineering work and collaborates with frontier labs and enterprises to simulate complex tasks, helping clients train and adapt the next generation of coding agents.

Crucibl

San Francisco

Proximal builds realistic training environments that mirror software engineering work and collaborates with frontier labs and enterprises to simulate complex tasks, helping clients train and adapt the next generation of coding agents.

Onyx

San Francisco

Onyx is an open-source AI assistant that aggregates company documents, apps, and people (Slack, Google Drive, Confluence, GitHub) to provide immediate answers from a single interface, with 24/7 availability and customizable assistants; foun

Lemon Slice

San Francisco

Lemon Slice is building a video foundation model for human motion and emotion, backed by a $6M seed from Y Combinator, Matrix Partners, The Chainsmokers and others; it has generated 1M+ videos and trains models as part of GenAI strategy.

Hamilton AI

San Francisco

Hamilton AI is building the operating system for business aviation, replacing fragmented communications with a fully integrated platform that uses AI to support scheduling, trip management, and operational decision-making, delivering real-t

Known Dating

San Francisco

Known positions itself as a generational companion for dating, friendships, and networking, supporting connections across diverse contexts and accompanying people through the full spectrum of relationships.

Dosu

San Francisco

Dosu makes engineering knowledge accessible to developers, empowering the community with AI-driven tools. A small San Francisco-based team backed by over $9M in funding, its software is used on thousands of open-source GitHub repos and supp

Highlight

San Francisco

The company markets itself as an on-screen personal assistant and aims to make users 10x faster at their jobs, positioning its product as a tool to streamline work and speed up daily tasks through on-screen assistance.

Unsiloed AI

San Francisco

Unsiloed AI provides production-grade APIs that ingest, parse, structure, and split documents into Markdown and JSON, preserving hierarchy and domain-specific context for Finance, Legal, and Healthcare workflows, enabling reliable AI/LLM us

Subhub

San Francisco

SubHub automates construction estimating by converting blueprints into estimator-ready takeoffs, reducing a 3+ month manual process to days.

Sphinx

San Francisco

Sphinx builds AI analysts that operate inside browsers and internal systems. Its agents, used by banks and fintechs across the United States, Canada, Europe, and Latin America, handle 90% of manual work and cut costs by 4x.

Altara

San Francisco

Altara is a San Francisco startup building an AI co-scientist for the physical world to accelerate breakthroughs in semiconductors, batteries, materials, chemicals, and aerospace, aiming to define a new AI-for-science category; backed by Gr

Overtone

San Francisco

Overtone, led by the founder and former CEO of Hinge, is building a new kind of dating service to help daters find someone who truly resonates. It has an office in New York City that emphasizes in-person collaboration.

Vmax

San Francisco

Vmax is an applied research lab at the frontier of reinforcement learning, developing techniques to leverage RL with Large Language Models.

Runloop

San Francisco

Runloop focuses on infrastructure and orchestration for AI agents, aiming to power the Agentic Web. With a small team of engineers formerly from Google and Stripe, it tackles productionizing AI for software engineering at scale.

Abacus

San Francisco

Abacus builds AI agents to automate tedious accounting workflows, redefining how accounting firms operate. It serves large enterprise clients, generates meaningful revenue, and is led by a two-person founding team backed by top-tier investo

Statics

San Francisco

Statics is building Context OS for AI agents to optimize context and improve LLM performance. Backed by Tier 1 VCs, including a16z, it works with a portion of Forbes AI 50 and is an early-stage company led by Johnny Wang.

Lumena

San Francisco

Lumena empowers domain experts to build AI-powered enterprise applications, enabling humans and AI to collaborate across systems such as Salesforce, NetSuite, and HubSpot. Its design partners include mid-market and enterprise companies in f

Onos Health

San Francisco

Onos Health is a San Francisco-based early-stage startup building an AI-powered platform to reduce waste in U.S. healthcare spending by aligning providers and payers, with a $6M seed round, live partnerships with major health plans, and exp

Assert

San Francisco

Assert.dev is building a modern code-review interface for AI-enabled development, guided by the slogan "Code is meant to be run, not read." It operates the assert.dev website and aims to modernize code review for the AI era.

XOXO AI

San Francisco

XOXO AI is a stealth research lab building consumer social AI that predicts user needs and fulfills them without prompts, aiming to democratize intelligent interfaces. It is assembling engineers, designers, and researchers to lead the next

Muro

San Francisco

Muro AI provides AI agents for Architectural, Engineering and Construction firms to automate pre-construction activities such as scoping and bid leveling, aiming to transform $2 trillion construction industry; led by CEO Kalyan Gautham, CTO

Variant

San Francisco

Variant is building a code generation platform that aims to bring generative creativity to design tools, and it is well-capitalized and backed by notable investors.

Deepnight

San Francisco

Deepnight develops a low-light camera embedded with an AI model to enable robots, drones, autonomous vehicles, and head-mounted displays to operate in total darkness, delivering enhanced vision in extreme lighting conditions.

Crewline AI

San Francisco

Crewline AI retrofits heavy equipment with plug-and-play autonomy and teleoperation kits, enabling autonomous or teleoperated operation on real construction sites across any vehicle. Its hybrid autonomy-plus-human-in-the-loop approach suppo

Mesa

San Francisco

Mesa builds next-generation developer tools focused on code review, quality, and productivity. Backed by Innovation Endeavors, Essence VC, South Park Commons, and leaders like Thomas Wolf of Hugging Face, it aims to reshape software develop

Roger Healthcare

San Francisco

Roger uses generative AI to alleviate staffing shortages in home health care, with full deployment at agencies serving tens of thousands of patients daily.

Phinity

San Francisco

Phinity creates AI training environments and distills expert engineering workflows into reinforcement learning environments across hardware, AI, mechanics, and manufacturing to enable AI to master engineering skills that reshape civilizatio

Radical Healthcare

San Francisco

Radical, a San Francisco-based company, aims to give every cancer patient access to the world’s best oncologist and holds exclusive access to a 400+ million-note, 8 million-record cancer dataset, backed by an elite advisory board and top-ti

Continue

San Francisco

Continue is a San Francisco–based startup (YC S23) backed by Heavybit and notable angels; Siemens is rolling out Continue, which has 26k+ GitHub stars and 2M+ downloads, and focuses on amplifying developers at the intersection of AI and dev

Vals AI

San Francisco

Vals AI is building the standard for evaluating real-world performance of large language models, originating from Stanford NLP evaluation research. Its $5 million seed round and its evaluations are used by major foundation model labs, enter

Pax

San Francisco

Pax is the first AI-powered duty drawback broker that automates and optimizes duty refunds, delivering 15% more refunds and a 99% reduction in processing time, founded by experts from Charter Brokerage, MIT, Google, Amazon, and Flexport.

Klarity

San Francisco

Klarity Health provides high-quality, worry-free and low-cost telehealth services, ensuring comprehensive care is within reach. Whether you're seeking mental health support, weight management, or counseling and therapy, Klarity is your trusted marketplace for health and well-being. We have facilitated over 350,000 telehealth visits and are trusted by 80,000+ patients and 400+ medical specialists. Check out our 5-star ratings: https://www.reviews.io/company-reviews/store/helloklarity

Thunder Compute

San Francisco

Thunder Compute, backed by Y Combinator, raised a $4.5 million seed round and aims to revolutionize GPU utilization, with over $500,000 in revenue in six months and rapid scaling.

Willow

San Francisco

Willow is building a voice operating system that enables computer control via voice, writes for you today, takes actions for you tomorrow, and anticipates needs before you ask. It has Uber adoption; backed by Y Combinator and Box Group.

Remy

San Francisco

Remy builds autonomous AI product teams, beginning with design agents, to provide a 24/7 visual exploration and brainstorming partner for software teams, with the aim of becoming an autonomous teammate that ideates, designs, and ships softw

Soma Health

San Francisco

Soma is a neurotechnology company developing the world's first software brain-computer interface, making brain health measurable and actionable without proprietary hardware. Based in San Francisco, it is a pre-launch consumer software compa

Latent

San Francisco

Latent develops AI-driven medical intelligence software to optimize hospital and clinic workflows, speed medication access for patients, and boost provider revenues, collaborating with major healthcare systems to expand fast, affordable pro